Topoisomerase II Mediated DNA Strand Cleavage and Antitumor Activities against Murine Leukemia P388 of Novel Acridines
نویسندگان
چکیده
منابع مشابه
Antitumor quinolones with mammalian topoisomerase II mediated DNA cleavage activity.
Ninety quinolones were evaluated to determine whether their ability to induce mammalian topoisomerase II mediated DNA cleavage in vitro correlated with their antitumor activity in vivo. Ten quinolones generated linear DNA at a yield of more than 10% of substrate supercoiled DNA in the mammalian topoisomerase II mediated DNA cleavage assay. All of these compounds showed a significant increase in...
متن کاملDrosophila topoisomerase II double-strand DNA cleavage: analysis of DNA sequence homology at the cleavage site.
In order to study the sequence specificity of double-strand DNA cleavage by Drosophila topoisomerase II, we have mapped and sequenced 16 strong and 47 weak cleavage sites in the recombinant plasmid p pi 25.1. Analysis of the nucleotide and dinucleotide frequencies in the region near the site of phosphodiester bond breakage revealed a nonrandom distribution. The nucleotide frequencies observed w...
متن کاملUCT1072s, new antitumor antibiotics with topoisomerase II mediated DNA cleavage activity, from Aspergillus sp.
referred to as "topoisomerase II poisons", trap the enzyme in an intermediate complex with DNAwhich prevents the final rejoining step of the reaction and results in increased DNAstrand breaks2). Nowit is generally accepted that the ability to form a cleavable complex with topoisomerase II is responsible for the antitumor activity of these drugs3). In order to identify a specific newtopoisomeras...
متن کاملUCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity, from Streptomyces sp.
DNAtopoisomerases are enzymes that alter DNA conformation through a concerted breaking and rejoining of DNAstrands thereby controlling the topological state of DNA1}. Topoisomerase II has been shown to be the primary cellular target for a numberof clinically important antitumor agents with diverse and unrelated chemical structures2'3*. These antitumor drugs, referred as to "topoisomerase II poi...
متن کاملThioguanine substitution alters DNA cleavage mediated by topoisomerase II.
Thiopurines and topoisomerase II-targeted drugs (e.g., etoposide) are widely used anticancer drugs. However, topoisomerase II-targeted drugs can cause acute myeloid leukemia, with the risk of this secondary leukemia linked to a genetic defect in thiopurine catabolism. Chronic thiopurines result in thioguanine substitution in DNA. The effect of these substitutions on DNA topoisomerase II activit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1994
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.114.5_304